Blau syndrome is a rare, autosomal dominant autoinflammatory disorder arising from mutations in the NOD2 gene, a key regulator of the innate immune response. It is classically defined by a triad of ...

Neutrophils induce anti-inflammatory -- or M2 -- macrophages deep in their granulocyte core. The dense globular structures of granulomas in animals, particularly in the lungs, have been studied.

Background A 21-year-old white male with a 3-year history of back pain presented with a 6-month history of weight loss (without significant gastrointestinal symptoms), lethargy and left hip pain, and ...

Chronic granulomatous disease (CGD) describes an inherited genetic condition that affects a person’s immune system. It results in a type of immunodeficiency and causes people to be highly susceptible ...

Kyoto, Japan -- When our bodies become infected, various immune responses are triggered, starting with a release of granulocytes, white blood cells containing special enzymes that make up about half ...

Chronic granulomatous disease (CGD) is a rare genetic immunodeficiency associated with phagocyte function. It was first described in the 1950s. It is caused due to functional impairment in the NADPH ...

Rao and colleagues have proposed that there are four histopathological subtypes of necrotizing scleritis: zonal necrotizing granulomatous inflammation (Figure 3a); diffuse or 'nonzonal' inflammation ...

CHICAGO--(BUSINESS WIRE)--Xentria Inc., a biotech company focused on developing novel biologics to address unmet clinical needs, presented its first set of data showing its novel biologic, XTMAB-16, ...

When Candace Smith first discovered a painful lump in her breast at age 37, she never imagined it would lead to rare diagnosis. Now 52, the North Carolina woman told Newsweek about her experience with ...