(Left) Nicotine withdrawal reduces nicotinic receptor activity, leading to a relative increase in muscarinic receptor activity and disrupting acetylcholine signaling balance. (Right) Suppressing ...

This is a preview. Log in through your library . Abstract Emerging studies indicate that striatal cholinergic interneurons play an important role in synaptic plasticity and motor control under normal ...

Vanderbilt University has synthesized muscarinic M4 receptor positive allosteric modulators (PAMs) reported to be useful for the treatment of Alzheimer’s disease, pain, schizophrenia and sleep ...