This protocol describes how to appropriately design a genetic association case–control study, either focusing on a candidate gene (CG) or region or implementing a genome-wide approach. The steps ...

For a desired power of detecting the association between a disease and several potential risk factors in case-control studies, Yang (1978, Biometrika 65, 635-640) and Halperin (1980, Biometrika 67, ...

We discuss design and analysis of longitudinal studies after case-control sampling, wherein interest is in the relationship between a longitudinal binary response that is related to the sampling (case ...