Dr. Otis Brawley answers the question: 'What Is High-Grade PIN?' March 16, 2009 -- Question: What is high-grade PIN (prostatic intraepithelial neoplasia)? Answer: High-grade prostatic intraepithelial ...

High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence. This lesion is characterized by cellular ...

Focusing development efforts for cancer-preventive drugs on precancerous lesions (that is,intraepithelial neoplasia (IEN)) can reduce costs and accelerate the emergence of new cancer-preventive drugs.