本研究针对CRBN（Cereblon）基PROTACs（蛋白降解靶向嵌合体）设计难题，开发了结合HADDOCK蛋白-蛋白对接与诱导拟合PROTAC对接的计算方法。通过验证26个晶体结构，证实该方法对CRBN复合物建模的高精度，并应用于ATR（Ataxia telangiectasia and RAD3-Related）激酶PROTACs设计，为 ...

SYRACUSE, N.Y. - Fishermen set off in their trawlers from the Boston Harbor at dawn in search of haddock and cod. After catching their fill, the fishers rush back to the harbor to sell their haul. The ...

Haddock is available fresh or frozen, usually as a fillet, but very occasionally as a whole, headless fish. In the spring, haddock roe are also available; they can be poached or fried. Haddock is also ...

PORTLAND, Maine - A staple seafood species caught by East Coast fishers for centuries is experiencing overfishing, and regulators have cut catch quotas by more than 80% to prevent the fish's ...

Recently I made fish for dinner and I showed you yesterday how I grilled the salmon. I also made some haddock with that same meal but I baked it and although it's a step or two more than grilling, I ...

You probably consume several types of fish without knowing about their health benefits. Here’s another fish you should try: The haddock is packed with minerals, omega-3 fatty acids, and B vitamins, ...

Doris “Granny D” Haddock, a New Hampshire woman who walked across the country at age 89 to promote campaign finance reform and later waged a quixotic campaign for the U.S. Senate, has died. She was ...