The Longevity Experts on Instagram: "« How Resveratrol Activates Longevity Pathways | Dr. David Sinclair » Dr. David Sinclair (@davidasinclair) discusses the discovery of resveratrol and its role in activating longevity pathways. 🌿 In the early 2000s, Dr. Sinclair and his team found that plant polyphenols like resveratrol—found in grapevines and red wine—could activate sirtuin enzymes, which are key to promoting health and longevity in mammals, including humans. While resveratrol gained hype, e